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Background Information

Type 2 Diabetes

At present, nearly 8.5 million people in Germany are known to have type 2 diabetes. Additionally, many if not millions are suspected to have not been diagnosed because the disease frequently has no symptoms in the beginning and is only recognized years later. Type 2 diabetes often leads to serious complications, such as blindness, kidney failure, and amputation of extremities. In addition, individuals with type 2 diabetes die earlier, especially of cardiovascular diseases.

Cardiovascular diseases

The term cardiovascular diseases describes the many different diseases of the heart and blood vessels. These include heart attacks and strokes, which occur when tissue parts of the heart or brain are not supplied with sufficient blood or when corresponding blood vessels rupture. Heart attacks and strokes usually come unexpected to those affected and can lead to impaired physical performance, long-term motor and neuronal consequential damage, and, in the worst case, death.

What do the results of the tests mean?

The tests show how you can personally help to prevent type 2 diabetes, a heart attack, or a stroke.

Please note: Even people with a low risk can develop type 2 diabetes, a heart attack, or stroke, whereas those with a high risk may remain healthy. Avoiding or reducing risk factors are thus no guarantee that the disease will not develop.

Risk factors for type 2 diabetes, heart attacks, and strokes

Unalterable factors that affect your risk for type 2 diabetes, heart attacks, and strokes:

  • Sex

    Studies have shown that men have a higher risk of cardiovascular disease than women.

  • Age

    The risk for diabetes, heart attacks, and strokes increases with age.

  • Body height

    Height has an influence on diabetes risk because it affects the distribution of abdominal fat.

  • Diseases in the family

    The risk is higher when blood relatives have had or have type 2 diabetes, a heart attack, or stroke. This increased risk is probably due to an interaction between genetic and family-specific lifestyle factors.

Alterable factors that affect your risk for type 2 diabetes, heart attacks, and strokes:

  • High blood pressure

    Physical activity helps to maintain a lower body weight and thus waist circumference. At the same time, it lowers blood pressure, among other things. It also improves insulin action, which helps regulate blood sugar levels. In addition to sports, other activities such as cycling, gardening or walking also contribute to a lower risk of type 2 diabetes.

  • Physical activity

    Physical activity helps to maintain a lower body weight and thus waist circumference. At the same time, it lowers blood pressure, among other things. It also improves insulin action, which helps regulate blood sugar levels. In addition to sports, other activities such as cycling, gardening or walking also contribute to a lower risk of type 2 diabetes.

  • Excess weight (waist circumference)

    When excess fat is deposited in the abdomen (waist), there is an increased risk of developing diabetes, heart attacks, and strokes. Studies have shown that weight reduction can reduce the risk of type 2 diabetes and cardiovascular diseases considerably.

  • Whole grain products

    Many studies have shown that eating whole grain products, such as whole grain bread and rolls, cereal flakes, grains and muesli, lowers the risk of type 2 diabetes, heart attacks, and strokes.

  • Meat

    The consumption of red meat, e. g. beef, pork, or lamb, increases the risk of type 2 diabetes, heart attacks, and strokes. The more you eat these meats, the higher your risk.

  • Coffee

    Many studies have discovered a relationship between regular coffee consumption and a lowered risk of type 2 diabetes, heart attacks, and strokes. The reason for this is not known. If you like to drink coffee and tolerate it well, there is at present no reason why you should not drink coffee in moderate amounts.

  • Smoking

    Smoking has been linked to an increased risk of type 2 diabetes, heart attacks, and strokes. It can also cause cancer, heart, and circulatory diseases. It is therefore recommended to quit smoking.

  • Soft drinks and sodas

    Various studies have shown that sugar-sweetened beverages such as sodas and soft drinks can increase the risk of cardiovascular diseases.

  • Vegetable oils

    Vegetable oils with a high proportion of unsaturated fatty acids, such as olive, rapeseed, or sunflower oil, can reduce the risk of cardiovascular disease.

How is your personal risk estimated?

The risk estimation is based on correlations observed in the Brandenburg Nutrition and Cancer Study (EPIC-Potsdam Study). The study, in which 27,548 adult men and women participate, was launched in 1994. It is part of the largest prospective European nutrition study to date (European Prospective Investigation into Cancer and Nutrition - EPIC) with 23 centers in 10 European countries. The study investigates the relations between nutrition and cancer, type 2 diabetes, cardiovascular diseases, and other chronic diseases.

The questions in the DIfE - German Diabetes Risk Score and the DIfE - Cardiovascular Disease Risk Score correspond to factors that contribute in varying degrees to the risk of developing type 2 diabetes, heart attacks, or strokes. Each factor has a certain value, which is multiplied with the value you have entered for this factor. The sum of these calculations makes it possible to estimate your risk of developing type 2 diabetes, a heart attack, or stroke within the next 10 years.

The methods for calculating the 10-year risk for diabetes, a heart attack, and stroke were tested for validity in the EPIC-Heidelberg study with 25,543 participants and, for diabetes risk, additionally in the German-representative German National Health Interview and Examination Survey 1998 cohort with 3,959 participants. The development, validation and extension of the DIfE - German Diabetes Risk Score and the DIfE - Cardiovascular Disease Risk Score have been published in renowned scientific journals such as Diabetes Care, Diabetes Research and Clinical Practice, BMJ Open Diabetes Research & Care, and Scientific Reports.